supercritical CO2 extraction machine

5 Factors Affecting Supercritical CO2 Extraction

pressure, temperature, time, solvent-to-material flow ratio , solvent flow rate.

Four steps of supercritical CO2 extraction

It is generally believed that solid solutes are physically, chemically or mechanically immobilized on a porous substrate.

Four steps

Many scholars believe that for supercritical CO2 extraction of natural products, the following four steps can be used to describe the mass transfer process:

  1. Supercritical fluid diffuses into the microporous structure of the natural matrix;
  2. The extracted components solvate with the supercritical fluid in the natural matrix;
  3. The solute dissolved in the supercritical fluid diffuses with the supercritical fluid through the porous matrix to the flowing supercritical fluid body;
  4. Mass transfer between the extract and the main body of the supercritical fluid in the fluid extraction zone

Which of the above 4 steps is a control step depends on the type and magnitude of the solute to be extracted, the matrix, and the force existing between the solute and the matrix to be extracted.

Because supercritical fluids have higher diffusion coefficients, and generally the solubility of high-boiling-point solutes in supercritical fluids is very low, the above mentioned is often a control step


The main factors affecting the extraction rate of supercritical CO2 extraction include extraction pressure, extraction temperature, extraction time, solvent-to-material flow ratio and solvent flow rate.

From a mass transfer perspective:

  1. Increasing the temperature can increase the vapor pressure of the solute, which is conducive to improving its volatility and diffusivity and providing the thermal energy necessary for the solute to be extracted to overcome its kinetic energy barrier during dissociation. However, increasing the temperature will also reduce the density of the supercritical fluid and reduce its extraction capacity, and the excessively high extraction temperature will also cause the degradation of the heat-sensitive substances. Factor constraints.
  2. An increase in pressure at a constant temperature will increase the density of the supercritical fluid, thereby increasing the extraction capacity of the supercritical fluid, but the pressure is limited by the equipment conditions.
  3. Properly increasing the flow rate and the ratio of solvent to raw material of the supercritical fluid will increase the mass transfer rate, but too fast a flow rate will make the residence time of the extraction solvent too short, resulting in a reduction in the contact time with the extract.
  4. Supercritical extraction is a typical operation at high solvent / feed ratio, high space velocity and low viscosity. Any measure that can increase the solvent diffusion coefficient, reduce the diffusion distance and eliminate the diffusion barrier will increase the mass transfer rate.


CO2 Extraction Machine Buyer’s Guide

As you can imagine, not all supercritical CO2 extractors are made the same.
For more than 30 years, we have customized many CO2 extraction machines (Tabletop CO2 Extractor) for many companies and university laboratories (1 lb CO2 extractor). Because each customer’s CO2 extraction process requirements are different, there are almost no identical machines.

How many liters of CO2 extraction vessel are needed?

The first factor that determines the size of the CO2 extraction vessel is the daily working hours of the plant, which determines the daily extraction batch. The vessel size of the CO2 extractor depends on the biomass to be processed per day.

Read More

How many separators are needed?

How can I custom my separator when I need more terpenes in my How can I custom my separators when need more terpenes in CBD oil extraction process?
Waxes separation and Light oil separation in 1st separator;
Light oil separation in 2nd separator;
To trap lightest and volatile compounds in 3rd separator.
It is important to choose the right vessel size that will meet your current needs as well as future demand.

Read More

How many pressure is best for your CO2 extraction process requirements?

The choice of CO2 extraction pressure is a changing factor. If the extraction pressure is too high, the useless substances in the plant will be extracted, such as wax and chlorophyll. If the extraction pressure is too low, the extraction time will be increased.

Read More

How can the minimum operating costs be achieved?

Read More

Further Reading: CBD Oil CO2 Extraction Machine

Simply the most complete
CO2 extraction process you can find

CO2 Extraction Process

From raw material preparation, we offer you the most complete CO2 essential oil extraction process.
At the same time, more than 100 CO2 essential oil extraction methods from the laboratory are also provided for you.


how to extract essential oils

Detailed explanation of CO2 extraction process steps of plant essential oils。

Read More

how to extract cbd

About the co2 extraction machine cannabis.
You can read a lot of articles about cbd oil extraction from the Internet, but I can tell you for sure that they are not comprehensive at all, and even have wrong descriptions.

Let’s start reading